Table 3

Univariate and multivariate contribution of fibrinogen, platelets, FXIII and sCD40L to the variation in TEG maximum amplitude (MA) in trauma patients stratified according to ISS (gr. 2 ISS > 26, gr. 1 ISS 15-26, gr. 0 ISS < 15)

Univariate

Multivariate (model 1)

Multivariate (model 2)

Unit

β (SE)

p

β (SE)

p

β (SE)

p


ISS > 26 (n = 23)

R2 = 0.47

R2 = 0.76

Fibrinogen

1 g/l

6.59 (1.85)

0.002

5.61 (1.86)

0.007

4.65 (1.31)

0.002

Platelets

10 *109/l

0.48 (0.28)

0.094

0.29 (0.25)

0.438

0.42 (0.18)

0.032

FXIII

1%

0.43 (0.20)

0.043

0.24 (0.19)

0.212

0.17 (0.13)

0.210

sCD40L

100 pg/ml

-1.62 (0.53)

0.006

-

-

-1.62 (0.35)

< 0.001

ISS 15-26 (n = 26)

R2 = 0.75

R2 = 0.76

Fibrinogen

1 g/l

6.84 (1.08)

< 0.001

6.33 (0.96)

< 0.001

5.84 (1.04)

< 0.001

Platelets

10 *109/l

0.41 (0.20)

0.047

0.37 (0.13)

0.011

0.44 (0.14)

0.006

FXIII

1%

0.13 (0.11)

0.245

0.01 (0.07)

0.847

0.03 (0.07)

0.712

sCD40L

100 pg/ml

-0.95 (0.89)

0.300

-

-

-0.73 (0.61)

0.250

ISS < 15 (n = 30)

R2 = 0.41

R2 = 0.41

Fibrinogen

1 g/l

3.55 (1.12)

0.004

3.26 (1.05)

0.005

3.29 (1.07)

0.005

Platelets

10 *109/l

0.34 (0.13)

0.017

0.30 (1.05)

0.019

0.28 (0.13)

0.038

FXIII

1%

0.00 (0.04)

0.986

0.00 (0.03)

0.995

-0.00 (0.03)

0.984

sCD40L

100 pg/ml

0.38 (0.44)

0.403

-

-

0.15 (0.38)

0.691


Univariate and multivariate regression analysis showing regression coefficients (β) with standard errors (SE) and p-values, with p-values in bold for variables with p < 0.05. The β corresponds to the predicted change in TEG MA (mm) associated with one unit increase in fibrinogen, platelet count, FXIII and/or sCD40L.

Ostrowski et al. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2011 19:64   doi:10.1186/1757-7241-19-64

Open Data